BMP-6 Recombinant Protein

ProSci
Product Code: PSI-40-204
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-40-204-0.002mg0.002mg£300.00
Quantity:
PSI-40-204-0.01mg0.01mg£428.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized BMP-6 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted BMP-6 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, expos

Documents

Further Information

Additional Names:
VGR, VGR1, VGR, Bone morphogenetic protein 6, VG-1-related protein, BMP-6
Background:
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
Biological Activity:
Biological activity was determined by its ability to induce alkaline phosphatase production by ATDC - 5 cells. The expected ED50this effect is 0.03 - 0.06 μg/mL.
NCBI Gene ID #:
654
NCBI Official Name:
bone morphogenetic protein 6
NCBI Official Symbol:
BMP6
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001709.1
Protein GI Number:
4502425
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P22004