DKK-1 Recombinant Protein

ProSci
Product Code: PSI-40-225
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-40-225-0.002mg0.002mg£300.00
Quantity:
PSI-40-225-0.01mg0.01mg£428.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized DKK-1 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted DKK-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, expos

Documents

Further Information

Additional Names:
SK, DKK-1, Dickkopf-related protein 1, SK, Dickkopf-1
Background:
DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.
Biological Activity:
Determined by its ability to inhibit mWnt3a-induced TCF/LEF-luciferase activity in reporter HEK293 cells.
NCBI Gene ID #:
22943
NCBI Official Name:
dickkopf WNT signaling pathway inhibitor 1
NCBI Official Symbol:
DKK1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_036374.1
Protein GI Number:
7110719
Purity:
Greater than 97% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
O94907