TLR-3 Recombinant Protein

ProSci
Product Code: PSI-40-239
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-40-239-0.005mg0.005mg£300.00
Quantity:
PSI-40-239-0.025mg0.025mg£428.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized TLR-3 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TLR-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, expos

Documents

Further Information

Additional Names:
CD283, IIAE2, Toll-like receptor 3
Background:
TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-κB pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells. Recombinant human TLR-3 is 77.0 kDa glycoprotein containing 681 residues which comprise the TLR-3 extracellular domain.
Biological Activity:
Biological activity was determined by its ability to neutralize Poly I:C induced NF-kappa beta signaling in HT-29 cells stably transfected with NF-kappa beta-luc. The ED50 for this effect is 5-10 ug/ml.?
NCBI Gene ID #:
7098
NCBI Official Name:
toll-like receptor 3
NCBI Official Symbol:
TLR3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_003256.1
Protein GI Number:
4507531
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
O15455