Secreted FRP-1 Recombinant Protein

ProSci
Product Code: PSI-40-224
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-40-224-0.005mg0.005mg£300.00
Quantity:
PSI-40-224-0.02mg0.02mg£428.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Secreted FRP-1 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Secreted FRP-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with

Documents

Further Information

Additional Names:
FRP, FRP1, FrzA, FRP-1, SARP2, FRP, Secreted frizzled-related protein 1, Secreted apoptosis-related protein 2
Background:
Secreted Frizzled Related Proteins (sFRPs) modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas. Recombinant human sFRP-1 is a glycosylated 283 amino acid protein containing a cysteine rich Frizzled homologous domain.
Biological Activity:
Biological activity was determined by its ability to inhibit BMP - 2 proliferation effect of ATDC - 5 cells. The expected ED50is 0.3-0.5 μg/mL.
NCBI Gene ID #:
6422
NCBI Official Name:
secreted frizzled-related protein 1
NCBI Official Symbol:
SFRP1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_003003.3
Protein GI Number:
56117838
Purity:
Greater than 97% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
HeLa cells
Swissprot #:
Q8N474