SCGF alpha Recombinant Protein

ProSci
Product Code: PSI-40-168
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-40-168-0.002mg0.002mg£300.00
Quantity:
PSI-40-168-0.01mg0.01mg£428.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized SCGF alpha recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted SCGF alpha is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any prot

Documents

Further Information

Additional Names:
P47, SCGF, LSLCL, CLECSF3, C-type lectin domain family 11 member A, C-type lectin superfamily member 3
Background:
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Human TGF-β1 is a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond.
Biological Activity:
The ED50 was determined by TGF - beta1's ability to inhibit the mouse IL - 4 - dependent proliferation of mouse HT - 2 cells is ≤ 0.05 ng/mL, corresponding to a specific activity of ≥ 2 x 107 units/mg.
NCBI Gene ID #:
6320
NCBI Official Name:
C-type lectin domain family 11, member A
NCBI Official Symbol:
CLEC11A
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_002966.1
Protein GI Number:
4506803
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Swissprot #:
Q9Y240