CD79 b Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-156-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD79b, B29, IGB, Ig-beta
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type (immunoglobulin-like) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.
Background References:
- Vasile S., et al., 1994, Mol. Immunol. 31:419-427.
- Luisiri P., et al., 1996, J. Biol. Chem. 271:5158-5163.
- Radaev S., et al., 2010, Structure 18:934-943.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
974
NCBI Official Name:
CD79b molecule, immunoglobulin-associated beta
NCBI Official Symbol:
CD79B
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
41.8 kDa
Protein Accession #:
NP_000617
Purity:
>92% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P40259