TNFRSF 14 Recombinant Protein

ProSci
Product Code: PSI-96-398
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-96-398-0.1mg0.1mg£657.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Documents

Further Information

Additional Names:
TNFRSF14, ATAR, HVEA, HVEM, LIGHTR, TR2, CD270
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.
Background References:
  • Hsu, H. et al., 1997, J. Biol. Chem. 272:13471.
  • Mauri, D.N. et al., 1998, Immunity 8:21.
  • Montgomery, R.I. et al., 1996, Cell 87:427.
  • Cheung,T.C.et al., 2005, Proc.Natl.Acad.Sci.USA102:13218-23.
Biological Activity:
Measured by its ability to inhibit TNF-beta-mediated cytotoxicity using L929 Mouse fibrosarcoma cells. The ED50 for this effect is typically 2. 5-10μg/ml in the presence of 1 ng/mL of recombinant human TNF-beta.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
8764
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
NCBI Official Symbol:
TNFRSF14
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
45.4 kDa
Protein Accession #:
NP_003811.2
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q92956