CD74 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-110-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD74, DHLAG, HLADG, II, Ia-GAMMA, p33, CLIP, INVG34
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.
Background References:
- Cresswell P., 1994, Annu. Rev. Immunol. 12: 259?93.
- Charest A., et al., 2003, Genes Chromosomes Cancer 37:58-71.
- Leng L., et al., 2003, J. Exp. Med. 197:1467-1476.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized human CD74 at 5μg/ml (100μl/well) can bind biotinylated human CTSL1 with a linear range of 3. 2 - 500 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
972
NCBI Official Name:
CD74 molecule, major histocompatibility complex, class II invariant chain
NCBI Official Symbol:
CD74
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
19.3 kDa
Protein Accession #:
NP_004346.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P04233