CD46 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-123-0.05mg | 0.05mg | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD46, AHUS2, MCP, MIC10, TLX, TRA2.10
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).
Background References:
- Lublin D.M., et al., 1988, J. Exp. Med. 168:181-194.
- Astier A., et al., 2000, J. Immunol. 164:6091-6095.
- Noris M., et al., 2003, Lancet 362:1542-1547.
- Kemper C., et al., 2003, Nature 421:388-392.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
4179
NCBI Official Name:
CD46 molecule, complement regulatory protein
NCBI Official Symbol:
CD46
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
33.6 kDa
Protein Accession #:
AAH30594.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P15529