CD3D Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-163-0.1mg | 0.1mg | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD3D, CD3-DELTA, T3D
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
CD3D is also known as CD3-DELTA, T3D, and is a single-pass type I membrane protein. CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+?SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.
Background References:
- Gil J, et al., 2011, J Clin Invest, 121(10):3872-6.
- Lu X, et al.,2011, Hematology, 16(3):185-9.
- Kim ST, et al., 2010, J Immunol, 185(5):2951-9.
- Holst, J. et al., 2008, Nat Immunol, 9 (6): 658-66.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
915
NCBI Official Name:
CD3d molecule, delta (CD3-TCR complex)
NCBI Official Symbol:
CD3D
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
11.4 kDa
Protein Accession #:
NP_000723.1
Purity:
>90% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P04234