CEACAM 6 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-179-0.1mg | 0.1mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CEACAM6, CD66c, CEAL, NCA
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) is also known as CD66c (Cluster of Differentiation 66c), CEAL, NCA, and is one of seven human CEACAM family members within the immunoglobulin superfamily. In humans, CEACAMs include type I transmembrane proteins (CEACAM1, CEACAM3, and CEACAM4) and GPI-linked molecules (CEACAM5 through CEACAM8). There is no human CEACAM2. CEACAM 6 contains one N-terminal V-type Ig-like domain (N domain), followed by two C2-type Ig-like domains. It shows considerable glycosylation, including (sialyl) LewisX, which mediates binding to E-selectin, galectins and some bacterial fimbrae. CEACAM-6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.
Background References:
- Beauchemin, N. et al., 1999, Exp. Cell Res. 252:243.
- Skubitz, K.M. et al., 1999, J. Biol. Regul. Homeost. Agents 13:244.
- Tawaragi, Y. et al.,1988, Biochem. Biophys. Res. Comm. 150:89.
- Scholzel, S. et al., 2000, Am. J. Pathol. 156: 595-605.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
4680
NCBI Official Name:
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
NCBI Official Symbol:
CEACAM6
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
32 kDa
Protein Accession #:
NP_002474.3
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P40199