Fetuin A Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-311-0.1mg | 0.1mg | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
AHSG, FETUA, Fetuin A
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Alpha-2-HS-glycoprotein (AHSG) is also known as Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A (FETUA), is a glycoprotein that is composed of two subunits, the A and B chains, belongs to the cystatin family of proteases inhibitors and the fetuin class of plasma binding proteins. AHSG / Fetuin A is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. Fetuins are carrier proteins like albumin. Fetuin-A / AHSG forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus AHSG / Fetuin A is a potent inhibitor of pathological calcification. Fetuin A / FETUA promotes phagocytosis of apoptotic cells and plays a role in bone development, calcium homeostasis and insulin sensitivity. Mice deficient in Fetuin-A show systemic calcification of soft tissues.
Background References:
- Jahnen-Dechent W., et al., 1994, Eur. J. Biochem. 226 : 59?69.
- Lee C., et al., 2009, Frontiers in Bioscience 14: 2911?2922.
- Heiss A., et al., 2008, J. Biol. Chem. 283 (21): 14815?25.
- Jahnen-Dechent W., et al., 2008, J. Mol. Med. 86 (4): 379?89.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
197
NCBI Official Name:
alpha-2-HS-glycoprotein
NCBI Official Symbol:
AHSG
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
38.2 kDa
Protein Accession #:
NP_001613
Purity:
>98% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P02765