IFNAR 2 Recombinant Protein

ProSci
Product Code: PSI-96-407
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-96-407-0.1mg0.1mg£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Documents

Further Information

Additional Names:
IFNAR2, IFNARB, IFNABR, IFN-R-2, IFN-alpha/beta receptor 2
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Interferon alpha/beta receptor 2 (IFNAR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFNABR and IFNARB, which is a single-pass type I membrane protein and belongs to the?type II cytokine receptor family. IFNAR2 can associate with IFNAR1 to form the type I interferon receptor. IFNAR2 is a receptor for interferons alpha and beta.IFNAR2 involves in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 of IFNAR2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 of IFNAR2 is a potent inhibitor of type I IFN receptor activity.Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection.
Background References:
  • Novick D., et al., 1994, Cell 77:391-400.
  • Novick D., et al., 1995, J. Leukoc. Biol. 57:712-718.
  • Li X., et al., 1997, Mol. Cell. Biol. 17:2048-2056.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
3455
NCBI Official Name:
interferon (alpha, beta and omega) receptor 2
NCBI Official Symbol:
IFNAR2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
25.6 kDa
Protein Accession #:
NP_997467
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P48551