Lipocalin 2 Recombinant Protein

ProSci
Product Code: PSI-96-507
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-96-507-0.1mg0.1mg£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Documents

Further Information

Additional Names:
NGAL, LCN2, Lipocalin-2, 24p3, MSFI
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Lipocalin-2 (LCN2) is also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), MSFI, The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor. LCN2 is strongly upregulated during inflammation and is upregulated by interleukin 1 (but not TNF alpha) in humans. There are indications that some forms of acne could be caused due to the gene not being transcribed, and that Isotretinoin corrects this. NFAT3 (NFATc4)NFAT by blocking the expression of LCN2 inhibits breast carcinoma cell motility. Recent studies have revealed that NGAL plays an important role in the physiopathology of chronic myeloid leukaemia (CML) mediated by BCR-ABL.
Background References:
  • Flo TH, et al., 2004, Nature 432 (7019): 917?21.
  • Schmidt-Ott KM, et al., 2007, J. Am. Soc. Nephrol. 18 (2): 407?13.
  • Nelson AM, et al., 2008, J. Clin. Invest. 118 (4): 1468?78.
  • Foug?re, M, et al., 2010, Oncogene 29 (15): 2292?301.
Biological Activity:
Measured by its ability to bind Iron(III) dihydroxybenzoic acid [Fe(DHBA)3]. The binding of Fe(DHBA)3 results in the quenching of Trp fluorescence in rhLCN2. rhLCN2 can bind >1. 5μM of Fe(DHBA)3.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
3934
NCBI Official Name:
lipocalin 2
NCBI Official Symbol:
LCN2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
22 kDa
Protein Accession #:
NP_005555.2
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P80188