CD58 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-514-0.1mg | 0.1mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD58, LFA3, Ag3
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
CD antigen CD58 is also known as Lymphocyte function-associated antigen 3 (LFA-3). CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) [3] on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.
Background References:
- Barbosa JA., et al., 1986, J. Immunol. 136 (8): 3085?91.
- Wang JH., et al., 1999, Cell 97 (6): 791?803.
- De Jager PL., et al., 2009, Proc Natl Acad Sci U S A. 106 (13): 5264?9.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
965
NCBI Official Name:
CD58 molecule
NCBI Official Symbol:
CD58
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
22.3 kDa
Protein Accession #:
AAH05930
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P19256