Mesothelin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-543-0.1mg | 0.1mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
MSLN, Mesothelin, MPF
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
Background References:
- Chang K., et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 93:136-140.
- Yamaguchi N., et al., 1994, J. Biol. Chem. 269:805-808.
- Rump A., et al., 2004, J. Biol. Chem. 279:9190-9198.
- Ma J., et al., 2012, J. Biol. Chem. 287:33123-33131.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
10232
NCBI Official Name:
mesothelin
NCBI Official Symbol:
MSLN
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
27.6 kDa
Protein Accession #:
AAH09272
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q13421