TNFRSF 18 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-353-0.05mg | 0.05mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
TNFSF18, AITRL, TL6, hGITRL, GITR Ligand
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.
Background References:
- Tuyaerts S., et al., 2007, J. Leukoc. Biol. 82:93-105.
- Chattopadhyay K., et al., 2007, Proc. Natl. Acad. Sci. U.S.A. 104:19452-19457.
Biological Activity:
Measured by its binding ability in a functional ELISA against immobilized Human GITR, His Tag (0.2ug/well). The linear range is 0.8-25 ng/mL.
Buffer:
50 mM tris, 100 mM glycine, pH7.5
Fusion Tag:
N-Fc Tag
NCBI Gene ID #:
8995
NCBI Official Name:
tumor necrosis factor (ligand) superfamily, member 18
NCBI Official Symbol:
TNFSF18
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
46.2 kDa
Protein Accession #:
AAH69319.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q9UNG2