IgG2a Fc Region Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-421-0.2mg | 0.2mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Immunoglobulin G2 (IgG2) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F(ab)s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. There are two members of IgG2: IgG2a and IgG2b. It was found that IgG2a was superior to IgG1 in activating complement. The glycosylation of the circulating immunoglobulin-γ (IgG) antibody molecules changes in rheumatoid arthritis.
Background References:
- Sikorav J.-L., et al., 1980, Nucleic Acids Res. 8:3143-3155.
- Ollo R., et al., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:2442-2446.
Buffer:
50 mM tris, 100 mM glycine, pH7.5
NCBI Gene ID #:
380793
NCBI Official Name:
immunoglobulin heavy constant gamma 2A
NCBI Official Symbol:
Ighg2a
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
26.4 kDa
Protein Accession #:
CAC20702
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P01863.1