ROR 1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-651-0.1mg | 0.1mg | £765.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
ROR1, NTRKR1
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.
Background References:
- Masiakowski P., et al., 1992, J. Biol. Chem. 267:26181-26190.
- Reddy U.R., et al., 1996, Oncogene 13:1555-1559.
- Greenman C., et al., 2007, Nature 446:153-158.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
26563
NCBI Official Name:
receptor tyrosine kinase-like orphan receptor 1
NCBI Official Symbol:
Ror1
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
68.4 kDa
Protein Accession #:
Q9Z139
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q9Z139