FGF-23 (human) (rec.) (His)
| Code | Size | Price |
|---|
| AG-40A-0114Y-C010 | 10 ug | £170.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
Blue Ice
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Fibroblast Growth Factor 23; Tumor-derived Hypophosphatemia-inducing Factor
Biological Activity:
Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells.
Concentration:
0.1mg/ml after reconstitution
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test; Lonza).
Form (Short):
solid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. Signal peptide and human FGF-23 (aa 1-251) are fused at the C-terminus to a His-tag. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Purity: >90% (SDS-PAGE). FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
Molecular Weight:
~30kDa (SDS-PAGE, full-length). FGF23 is cleaved between Arg179 and Ser180 (two bands of ~14kDa and ~16kDa).
NCBI, Uniprot Number:
Q9GZV9
Package Type:
Plastic Vial
Product Description:
FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
Purity:
>90% (SDS-PAGE)
Sequence:
Signal peptide and human FGF-23 (aa 1-251) are fused at the C-terminus to a His-tag.
Source / Host:
HEK 293 cells
TAGs:
His
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
References
Maternally-derived antibody to fibroblast growth factor-23 reduced dietary phosphate requirements in growing chicks: E.A. Bobeck, et al.; BBRC 420, 666 (2012) | Antibody to fibroblast growth factor 23-peptide reduces excreta phosphorus of laying hens: Z. Ren, et al.; Poultry Science 96, 127 (2017)