Convulxin
| Code | Size | Price |
|---|
| AG-CN2-0465-C050 | 50 ug | £870.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
CVX
Appearance:
Lyophilized.
Biological Activity:
<50ng/ml (minimal concentration to induce maximum activation of washed human platelets).
CAS:
37206-04-5
Class:
6.1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS06,GHS08
Handling Advice:
After opening, prepare aliquots and store at -80°C.Avoid freeze/thaw cycles.Protect from light and moisture.
Hazards:
H300, H330, H373
InChiKey:
MOSFIJXAXDLOML-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 37206-04-5. MW: ~84kDa. Isolated from Crotalus durissus terrificus snake venom. Glycoprotein GPVI receptor agonist. Can be used for studies on platelet receptors. Activates mammalian platelets via binding and clustering of GPVI-receptors under physiological conditions. Occupation and clustering of GPVI activates Src family kinases, phosphorylates Fc receptor gamma-chain and activates p72SYK that is critical for downstream activation of platelets. Causes cardiovascular and respiratory disturbances. Prostaglandins are strong inhibitors of convulxin-induced aggregation. Heterodimeric C-type lectin. Disulfide linked heterodimer consisting of homologous alpha and beta chains. The heterodimers are additionally linked by disulfide bridges to form cyclic alpha(4)beta(4)heterotetramers.
MDL:
MFCD01771615
Molecular Weight:
~84kDa
Other data:
Stock solutions are stable for 8 hours at +20°C, for 2 days at +4°C or for 1 month when stored at -80°C.
Package Type:
Vial
PG:
I
Precautions:
P260, P301, P310, P304, P340, P405
Product Description:
Glycoprotein GPVI receptor agonist. Can be used for studies on platelet receptors. Activates mammalian platelets via binding and clustering of GPVI-receptors under physiological conditions. Occupation and clustering of GPVI activates Src family kinases, phosphorylates Fc receptor gamma-chain and activates p72SYK that is critical for downstream activation of platelets. Causes cardiovascular and respiratory disturbances. Prostaglandins are strong inhibitors of convulxin-induced aggregation. Heterodimeric C-type lectin. Disulfide linked heterodimer consisting of homologous alpha and beta chains. The heterodimers are additionally linked by disulfide bridges to form cyclic alpha(4)beta(4)heterotetramers.
Purity:
>90% SDS-PAGE (partially purified by multi-step chromatography).
Signal Word:
Danger
Solubility Chemicals:
Soluble in organic buffer (HEPES).
Source / Host:
Isolated from Crotalus durissus terrificus snake venom.
Transportation:
Excepted Quantity
UN Nummer:
UN 3462
UNSPSC Category:
Toxins
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Convulxin, a new toxin from the venom of the South American rattlesnake Crotalus durissus terrificus: J. Prado-Franceschi & O.V. Brazil; Toxicon 19, 875 (1981) | Convulxin, a potent platelet-aggregating protein from Crotalus durissus terrificus venom, specifically binds to platelets: I.M. Francischetti, et al.; Toxicon 35, 1217 (1997) | Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor: J. Polgar, et al.; J. Biol. Chem. 272, 13576 (1997) | Convulxin-induced platelet adhesion and aggregation: involvement of glycoproteins VI and IaIIa: M. Jandrot-Perrus, et al.; Platelets 9, 207 (1998) | Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases: M. Cicmil, et al.; J. Biol. Chem. 275, 27339 (2000) | Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxin: B.T. Atkinson, et al.; Eur. J. Biochem. 268, 5242 (2001) | Convulxin binding to platelet receptor GPVI: competition with collagen related peptides: F. Niedergang, et al.; BBRC 273, 246 (2002) | Convulxin binds to native, human glycoprotein Ib alpha: S. Kanaji, et al.; J. Biol. Chem. 278, 39452 (2003)