alpha-Galactosylceramide Analog 8
| Code | Size | Price |
|---|
| AG-CR1-3622-C500 | 500 ug | £250.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
alpha-Gal-Cer Analog 8; alpha-Galactosylceramide Analog 5; alpha-Gal-Cer Analog 5
Appearance:
White solid.
CAS:
922727-14-8
EClass:
32160000
Form (Short):
solid
Handling Advice:
Aliquot into glass vials.
InChi:
InChI=1S/C50H97N3O8/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-42-39-53(52-51-42)43(41-60-50-49(59)48(58)47(57)45(40-54)61-50)46(56)44(55)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h39,43-50,54-59H,3-38,40-41H2,1-2H3/t43-,44+,45+,46-,47-,48-,49+,50-/m0/s1
InChiKey:
YLAIBGQPPXWHSD-MKADWPIHSA-N
Long Description:
Chemical. CAS: 922727-14-8. Formula: C50H97N3O8. MW: 868.3. Synthetic. Immunostimulant. Potent stimulator of natural killer T (NKT) cells. Specific ligand of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells. Potent antitumor compound. Stimulates the production of smaller amounts of IFN-gamma than alpha-GalCer, but induces equal or greater IL-4 secretion in mouse models.
MDL:
N/A
Molecular Formula:
C50H97N3O8
Molecular Weight:
868.3
Package Type:
Vial
Product Description:
Immunostimulant. Potent stimulator of natural killer T (NKT) cells. Specific ligand of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells. Potent antitumor compound. Stimulates the production of smaller amounts of IFN-gamma than alpha-GalCer, but induces equal or greater IL-4 secretion in mouse models.
Purity:
>96% (NMR)
SMILES:
CCCCCCCCCCCCCCCCCCCCCCCCC1=CN(N=N1)[C@@H](COC1OC(CO)C(O)C(O)C1O)[C@H](O)[C@H](O)CCCCCCCCCCCCCC
Solubility Chemicals:
Soluble in pyridine, methanol, 100% ethanol, DMSO or dimethylformamide.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Synthesis and evaluation of 1,2,3-triazole containing analogues of the immunostimulant alpha-GalCer: T. Lee, et al.; J. Med. Chem. 50, 585 (2007) | Phase transfer agent assisted biphasic CuAAC reaction: J.H. Kim & S. Kim; RSC Adv. 4, 26516 (2014)