PARP-1 [ARTD1] high purity Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-340-10ug | 10ug | £594.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
Dry ice
Storage:
Stable for at least 6 months after receipt when stored at -80˚C.
Documents
Further Information
Additional Names:
Poly(ADP-ribose) Polymerase 1, ADP-ribosyltransferase Diphtheria Toxin-like 1, NAD(+) ADP-ribosyltransferase 1
Application Note:
This recombinant proteins is for research use only.
Background:
PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
Biological Activity:
>1200U/mg protein.
Buffer:
In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol.
Concentration:
Lot dependent (0.2-0.5mg/ml)
Fusion Tag:
His Tag
NCBI Gene ID #:
57097
NCBI Official Name:
poly (ADP-ribose) polymerase family, member 11
NCBI Official Symbol:
PARP11
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
P09874
Protein GI Number:
156523968
Purity:
>98% (SDS-PAGE)
Recombinant Protein Sequence:
Thr32-Gly402
Source:
Sf21 cells
Swissprot #:
P13501