PARP-3 [ARTD3] high purity Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-342-10ug | 10ug | £594.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
Dry ice
Storage:
Stable for at least 6 months after receipt when stored at -80˚C.
Documents
Further Information
Additional Names:
Poly(ADP-ribose) Polymerase 3, ADP-ribosyltransferase Diphtheria Toxin-like 3, NAD(+) ADP-ribosyltransferase 3
Application Note:
This recombinant proteins is for research use only.
Background:
PARP-3 [ARTD3] is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Biological Activity:
>10U/mg protein (only monoADP-ribosyl transferase activity).
Buffer:
In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol.
Concentration:
Lot dependent (0.2-1mg/ml)
Fusion Tag:
His Tag
NCBI Gene ID #:
10039
NCBI Official Name:
poly (ADP-ribose) polymerase family, member 3
NCBI Official Symbol:
PARP3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q9Y6F1
Protein GI Number:
158634478
Purity:
>98% (SDS-PAGE)
Recombinant Protein Sequence:
Thr32-Gly402
Source:
Sf21 cells
Swissprot #:
O00626