anti-Slc7a8 [Lat2] pAb

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AdipoGen Life Sciences
Product Code: AG-25T-0120
Product Group: Primary Antibodies
CodeSizePrice
AG-25T-0120-C100100 ug£380.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
-20°C
Storage:
Short Tem: +4°C Long Term: -20°C

Images

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Western blot analysis of mouse kidney extract using anti-Slc7a8 [Lat2], pAb (AG-25T-0112) at a dilution of 1:800.
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Western blot analysis of mouse kidney extract using anti-Slc7a8 [Lat2], pAb (AG-25T-0112) at a dilution of 1:800.

Documents

Further Information

Alternate Names/Synonyms:
Solute Carrier Family 7 Member 8; Lat2; L-type Amino Acid Transporter 2; Large Neutral Amino Acids Transporter Small Subunit 2
Concentration:
0.5mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
Synthetic peptide corresponding to a partial sequence of mouse Slc7a8 (Q9QXW9).
Long Description:
Polyclonal Antibody. Recognizes mouse and human Slc7a8. Other species not tested.Detects a ~50kDa Slc7a8 band in wild type mouse brain, kidney, jejunum, ileum and other tissues, which is absent in knock-out animals. In some tissues the antibody detects an additional unknown 38kDa band. Source: Rabbit. Applications: IHC, WB. Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide. L-type amino acid transporter (LAT) family members are Na(+)-independent transporters, which deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 (SLC43A1) and LAT4 (SLC43A2) are responsible for the majority of cellular leucine uptake. They show increased expression in many cancers and are critical for control of protein translation and cell growth through the mTORC1 pathway. The increased transporter expression observed in cancers is regulated by transcriptional pathways such as hormone receptors, c-myc and nutrient starvation responses.
NCBI, Uniprot Number:
Q9QXW9
Package Type:
Plastic Vial
Product Description:
L-type amino acid transporter (LAT) family members are Na(+)-independent transporters, which deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 (SLC43A1) and LAT4 (SLC43A2) are responsible for the majority of cellular leucine uptake. They show increased expression in many cancers and are critical for control of protein translation and cell growth through the mTORC1 pathway. The increased transporter expression observed in cancers is regulated by transcriptional pathways such as hormone receptors, c-myc and nutrient starvation responses.
Purity:
Antigen affinity purified.
Source / Host:
Rabbit
Specificity:
Recognizes mouse and rat Slc7a8. Detects a ~50kDa Slc7a8 band in wild type mouse brain, kidney, jejunum, ileum and other tissues, which is absent in knock-out animals. In some tissues the antibody detects an additional unknown 38kDa band.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome: E.K. Wirth, et al.; J. Neurosci. 29, 9439 (2009) | Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8: D. Braun, et al.; Biochem. J. 439, 249 (2011) | Structural insights into thyroid hormone transport mechanisms of the L-type amino acid transporter 2: K.M. Hinz, et al. Mol. Endocrinol. 29, 933 (2015)