Raptinal
| Code | Size | Price |
|---|
| AG-CR1-2902-M001 | 1 mg | £35.00 |
Quantity:
| AG-CR1-2902-M005 | 5 mg | £70.00 |
Quantity:
| AG-CR1-2902-M025 | 25 mg | £190.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
Short Tem: +4°C, Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
[9,9'-Bi-9H-fluorene]-9,9'-dicarboxaldehyde; NSC 610970
Appearance:
Beige solid.
CAS:
1176-09-6
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.Keep under inert gas.Protect from moisture and oxygen.
Hazards:
H302
InChi:
InChI=1S/C28H18O2/c29-17-27(23-13-5-1-9-19(23)20-10-2-6-14-24(20)27)28(18-30)25-15-7-3-11-21(25)22-12-4-8-16-26(22)28/h1-18H
InChiKey:
GLANOOJJBKXTMI-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1176-09-6. Formula: C28H18O2. MW: 386.4. Rapid apoptosis inducer that initiates intrinsic pathway caspase-dependent apoptosis within minutes in multiple cell lines and in vivo systems. Exerts anticancer activity in vivo, likely through the induction of apoptosis. Induces cell death against various cancer and non-cancerous cell lines with 24 hour IC50 values between 0.7-3.4µM indicating activity across a wide range of cell lines. Activates the intrinsic pathway and requires functional mitochondria for apoptosis induction. Treated cells did not undergo mitochondrial-permeability-transition-pore (MPTP) formation, suggesting a mitochondrial outer membrane permeabilization (MOMP) model of cytochrome c release.
MDL:
MFCD30480931
Molecular Formula:
C28H18O2
Molecular Weight:
386.4
Other data:
Note: Use fresh solutions. Cyclizes in water/acidic conditions.
Package Type:
Vial
Precautions:
P301, P312
Product Description:
Rapid apoptosis inducer that initiates intrinsic pathway caspase-dependent apoptosis within minutes in multiple cell lines and in vivo systems. Exerts anticancer activity in vivo, likely through the induction of apoptosis. Induces cell death against various cancer and non-cancerous cell lines with 24 hour IC50 values between 0.7-3.4µM indicating activity across a wide range of cell lines. Activates the intrinsic pathway and requires functional mitochondria for apoptosis induction. Treated cells did not undergo mitochondrial-permeability-transition-pore (MPTP) formation, suggesting a mitochondrial outer membrane permeabilization (MOMP) model of cytochrome c release.
Purity:
>98% (NMR)
Signal word:
Warning
SMILES:
O=CC1(C2(C=O)C3=C(C=CC=C3)C4=C2C=CC=C4)C5=C(C=CC=C5)C6=C1C=CC=C6
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
A small molecule that induces intrinsic pathway apoptosis with unparalleled speed: R. Palchaudhuri, et al.; Cell Rep. 13, 2027 (2015) | The inflammasome drives GSDMD-independent secondary pyroptosis and IL-1 release in the absence of caspase-1 protease activity: K.S. Schneider, et al.; Cell Rep. 21, 3846 (2017)