NVP-BEZ235

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity: S.M. Maira, et al.; Mol. Cancer Ther. 7, 1851 (2008) | Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging: C.R. Schnell, et al.; Cancer Res. 68, 6598 (2008) | NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations: V. Serra, et al.; Cancer Res 68, 8022 (2008) | Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway: S.M. Maria, et al.; Future Med. Chem. 1, 137 (2009) | Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors: R. Marone, et al.; Mol. Cancer Res. 7, 601 (2009) | Chiarini F, Grimaldi C, Ricci F, et al. Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia: F. Chiarini, et al.; Cancer Res. 70, 8097 (2010) | NVP-BEZ235, a dual pan class I PI3 kinase and mTOR inhibitor, promotes osteogenic differentiation in human mesenchymal stromal cells: S.K. Martin, et al.; J. Bone Miner. Res. 25, 2126 (2010) | Recent results in protein kinase inhibition for tropical diseases: D.P. Rotella, et al.; Bioorg. Med. Chem. Lett. 22, 6788 (2012) | The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses: B. Mukherjee, et al.; Neoplasia 14, 34 (2012) | Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235: G.J. Cerniglia, et al.; Mol. Pharmacol. 82, 1230 (2012) | Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma: C.R. Gil del Alcazar, et al.; Clin. Cancer Res. 20, 1235 (2014) | Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-beta 1-42 induced neurotoxicity and memory impairment: P.M. Bellozi, et al.; Sci. Rep. 6, 25226 (2016)