AZD-8055
| Code | Size | Price |
|---|
| SYN-1166-M100 | 100 mg | Enquire |
Quantity:
| SYN-1166-M001 | 1 mg | £80.00 |
Quantity:
| SYN-1166-M005 | 5 mg | £127.00 |
Quantity:
| SYN-1166-M010 | 10 mg | £145.00 |
Quantity:
| SYN-1166-M050 | 50 mg | £385.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
AZD8055; CCG168
Appearance:
Solid.
CAS:
1009298-09-2
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Hazards:
H303, H317, H333
InChi:
InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1
InChiKey:
KVLFRAWTRWDEDF-IRXDYDNUSA-N
Long Description:
Chemical. CAS: 1009298-09-2. Formula: C25H31N5O4. MW: 465.5. AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase activity with an IC(50) of 0.8nM. It shows excellent selectivity (~1,000-fold) against all class I phosphatidylinositol 3-kinase (PI3K) isoforms and other members of the PI3K-like kinase family.
Molecular Formula:
C25H31N5O4
Molecular Weight:
465.5
Package Type:
Plastic Vial
Precautions:
P261, P272, P280, P302, P352, P333, P313, P321, P363, P501
Product Description:
AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase activity with an IC(50) of 0.8nM. It shows excellent selectivity (~1,000-fold) against all class I phosphatidylinositol 3-kinase (PI3K) isoforms and other members of the PI3K-like kinase family.
Purity:
>95%
Signal word:
Warning
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment: C. Garcia-Echeverria; Bioorg. Med. Chem. Lett. 20, 4308 (2010) | Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014: K.G. Pike, et al.; Bioorg. Med. Chem. Lett. 23, 1212 (2013)
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