SIGIRR (human):Fc (human) (rec.)

Toll/Interleukin-1 Receptor 8; TIR8; Single Ig IL-1R-related Molecule

After reconstitution:for 10µg size: 0.1mg/mlfor 50µg size: 1 mg/ml

32160000

<0.06EU/µg purified protein (LAL test; Lonza).

liquid

Lyophilized from 0.2µm-filtered solution in PBS.

After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.

Protein. Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.06EU/µg purified protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in PBS. Purity: >90% (SDS-PAGE). SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4.

~50kDa (SDS-PAGE)

AAH03591.1

Plastic Vial

SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4.

>90% (SDS-PAGE)

Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1.

HEK 293 cells

Fc

Non-hazardous

Other Proteins

12352202

Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.