GITRL, Soluble (human) (rec.) (His)

AdipoGen Life Sciences
Product Code: AG-40A-0024T
Product Group: Recombinant Proteins

CodeSizePrice
AG-40A-0024T-C01010 ug£100.00
Quantity:
AG-40A-0024T-C05050 ug£290.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Shipping:
Blue Ice
Storage:
Short term storage: +4°C Long term storage: -20°C

Further Information

Alternate Names/Synonyms:
Glucocorticoid-induced TNF Receptor Ligand; AITRL; Activation-inducible TNF-related Ligand; TNFSF18
Concentration:
After reconstitution:for 10µg size: 0.1mg/mlfor 50µg size: 1 mg/ml
EClass:
32160000
Endotoxin:
<0.06EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized from 0.2µm-filtered solution in PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. The extracellular domain of human GITRL (aa 74-199) is fused at the C-terminus to a His-tag. Source: HEK 293 cells. Endotoxin content: <0.06EU/µg purified protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in PBS. Purity: >90% (SDS-PAGE). GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
Molecular Weight:
~17kDa (SDS-PAGE)
NCBI, Uniprot Number:
AAH69319
Package Type:
Plastic Vial
Product Description:
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
Purity:
>90% (SDS-PAGE)
Sequence:
The extracellular domain of human GITRL (aa 74-199) is fused at the C-terminus to a His-tag.
Source / Host:
HEK 293 cells
TAGs:
His
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

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