P-Selectin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-939-0.1mg | 0.1mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
P-Selectin,CD62P,SELP,GMP-140
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
P-selectin (SELP) is also known as CD62 antigen-like family member P, granule membrane protein 140 (GMP-140), leukocyte-endothelial cell adhesion molecule 3 (LECAM3) and platelet activation dependent granule-external membrane protein (PADGEM). SELP functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets SELP is stored in alpha-granules. The primary ligand for SELP is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidan. Furthermore, SELP has a functional role in metastasis of tumor similar to E-selectin, which can help cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively.
Background References:
- Pouyani T., et al., 1995, Cell 83:333-343.
- Wilkins P.P., et al.,1995, J. Biol. Chem. 270:22677-22680.
- Kerr S.C., et al., 2008, J. Immunol. 181:1480-1490.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
6403
NCBI Official Name:
selectin P (granule membrane protein 140kDa, antigen CD62)
NCBI Official Symbol:
P-Selectin
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
81.8 kDa
Protein Accession #:
AAN06828
Purity:
>95% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P16109