CD47 Recombinant Protein

ProSci
Product Code: PSI-96-986
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-96-986-0.1mg0.1mg£729.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

Documents

Further Information

Additional Names:
CD47,MER6,IAP,OA3
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
Background References:
  • Lindberg F.P., et al., 1993, J. Cell Biol. 123:485-496.
  • Latour S., et al., 2001, J. Immunol. 167:2547-2554.
  • Piccio L., et al., 2005, Blood 105:2421-2427.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
16423
NCBI Official Name:
Leukocyte surface antigen CD47
NCBI Official Symbol:
CD47
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
40 kDa
Protein Accession #:
Q61735
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q61735