anti-PD-1 (mouse), mAb (blocking) (1H10) (preservative free)
Code | Size | Price |
---|
AG-20B-0075PF-C100 | 100 ug | £190.00 |
Quantity:
AG-20B-0075PF-C500 | 500 ug | £300.00 |
Quantity:
AG-20B-0075PF-M002 | 2 mg | £480.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: Rat IgG2aκ
Antibody Clonality: Monoclonal
Antibody Clone: 1H11
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Fluorescence-activated cell sorting (FACS)
- Functional Study
Shipping:
Blue Ice
Storage:
-200
Images
Further Information
Alternate Names/Synonyms:
CD279; Programmed Cell Death Protein 1
Concentration:
1mg/ml
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Liquid. In PBS.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Mouse PD-1 transfected cell line.
Labels - Conjugates:
Preservative Free
Long Description:
Monoclonal Antibody. Recognizes mouse PD-1 (CD279). Does not cross-react with human PD-1d. Isotype: Rat IgG2akappa. Clone: 1H10. Applications: FACS, FUNC (Blocking). Liquid. In PBS. CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
NCBI, Uniprot Number:
NP_005009.2
Package Type:
Plastic Vial
Product Description:
CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
Purity:
>95% (SDS-PAGE)
Source / Host:
Purified from concentrated hybridoma tissue culture supernatant.
Specificity:
Recognizes mouse PD-1 (CD279). Does not cross-react with human PD-1d.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
Antibody-mediated signalling through PD-1 costimulates T cells and enhances CD28- dependent proliferation: M.L. del Rio, et al.; Eur. J. Immunol. 35, 3545 (2005)
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