DLK1 Soluble (human) ELISA Kit
| Code | Size | Price |
|---|
| AG-45A-0032YEK-KI01 | 96 wells | £530.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
BLUE ICE
Storage:
40
Further Information
Alternate Names/Synonyms:
Protein Delta Homolog 1; pG2; Fetal Antigen 1; FA 1
Assay Type:
Sandwich
Detection Type:
Colorimetric
EClass:
32160000
Handling Advice:
After standard reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Plate and reagents should reach room temperature before use.
Long Description:
ELISA Assay. Detects human DLK1. Does not cross-react with human DLL1 or human DNER. Colorimetric assay. Sample Types: Cell Culture Supernatant, Serum. Range: 0.47 to 30ng/ml. Sensitivity: 336pg/ml. The Notch signaling pathway is essential for appropriate cell differentiation and cell fate decisions. DLK1 (Protein delta homolog 1; Preadipocyte factor 1; Pref-1) is a regulator of adipocyte differentiation found in serum and urine. DLK1 might be a decoy ligand. Serum or plasma levels of soluble DLK1 affect negatively or positively adipogenesis and control mesenchymal cell fate. DLK1 is frequently upregulated in myelodysplastic syndrome (MDS) patients compared to non-leukemic individuals.
NCBI, Uniprot Number:
P80370
Package Type:
Box
Product Description:
The Notch signaling pathway is essential for appropriate cell differentiation and cell fate decisions. DLK1 (Protein delta homolog 1; Preadipocyte factor 1; Pref-1) is a regulator of adipocyte differentiation found in serum and urine. DLK1 shifts nutrient metabolism towards FA oxidation. Serum or plasma levels of soluble DLK1 affect negatively or positively adipogenesis and control mesenchymal cell fate. DLK1 is frequently upregulated in myelodysplastic syndrome (MDS) patients compared to non-leukemic individuals. Fetus is the source of maternal circulating DLK1 during pregnancy. It has been recently reported that measurement of DLK1 in maternal blood may be a valuable method for diagnosing human disorders associated with impaired DLK1 expression, and to predict poor intrauterine growth and complications of pregnancy.
Range:
0.47 to 30ng/ml
Sample Type:
Cell Culture Supernatant, Serum
Sensitivity:
336pg/ml
Specificity:
Detects human DLK1. Does not cross-react with human DLL1, human DNER or mouse DLK1.
Transportation:
Non-hazardous
UNSPSC Category:
ELISA Kits
UNSPSC Number:
41116126
Use & Stability:
12 months after the day of manufacturing. See expiry date on ELISA Kit box.
References
Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation: G. Flehmig, et al.; PLos One 9, e99785 (2014) | Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction: M. Cleaton, et al.; Nat. Genet. 48, 1473 (2016)