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Phosphorylation

Histone phosphorylation of histone H3 at serine 10 and serine 28 is conserved through eukaryotes, and an increase in phosphorylation has been shown to correlate with gene activation and cell growth. By using the assay kits or antibodies provided by Caltag Medsystems, detection of changes in histone phosphorylation levels can provide useful information in better understanding the pathological processes of some diseases, and for protein kinase-targeted drug development. Monoclonal and polyclonal antibodies that detect phosphorylated target proteins help researchers to understand the role phosphorylation plays in cellular processes. Phosphorylation can turn on and off numerous protein enzymes by adding a phosphate group to the protein, thereby affecting their activity and function.

Histone phosphorylation modulators and inhibitors act to inhibit proteases and phosphatases for research investigating diseases connected to phosphorylation such as Alzheimer’s and Huntington’s disease.