AdipoGen Life Sciences

SR3677

Product Code:
 
SYN-1083
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term +4°C
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Chemical Structure
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Chemical Structure

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Further Information

Alternate Names/Synonyms:
SR-3677
Appearance:
Solid.
CAS:
1072959-67-1
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C22H24N4O4/c1-26(2)9-10-28-20-11-15(16-12-23-24-13-16)7-8-17(20)25-22(27)21-14-29-18-5-3-4-6-19(18)30-21/h3-8,11-13,21H,9-10,14H2,1-2H3,(H,23,24)(H,25,27)
InChiKey:
OQWZIAVXCYIZNN-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1072959-67-1. Formula: C22H24N4O4. MW: 408.5. Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively). SR-3677 had an IC(50) of approximately 3nM in enzyme and cell based assays and had an off-target hit rate of 1.4% against 353 kinases, and inhibited only 3 out of 70 non-kinase enzymes and receptors.
Molecular Formula:
C22H24N4O4
Molecular Weight:
408.5
Package Type:
Plastic Vial
Product Description:
Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively). SR-3677 had an IC(50) of approximately 3nM in enzyme and cell based assays and had an off-target hit rate of 1.4% against 353 kinases, and inhibited only 3 out of 70 non-kinase enzymes and receptors.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors: Y. Feng, et al.; J. Med. Chem. 51, 6642 (2008)