ProSci

CD71 Antibody [RI7217]

Product Code:
 
PSI-98-835
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
[RI7217]
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
blue ice
Storage:
 
Store vial at 2-8˚C
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PSI-98-835-0.5mg0.5mg£524.00
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Further Information

Additional Names:
T9, transferrin receptor, TfR
Application Note:
CD71 Antibody [RI7217] for use in flow cytometry, immunocytochemistry, western blotting, immunoprecipitation, blocking, separation, and drug delivery assays.
Background:
CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the transferrin receptor. It is essential for the growth of normal and neoplastic cells. It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens presumably reflecting the iron dependence of proliferation. Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron which is essential for many metabolic pathways through the binding and endocytosis of transferrin, the major iron-carrying protein. It may also be involved in signal transduction via its association with the T cell receptor ? chain. The monoclonal antibody RI7217 inhibits cell proliferation in vitro.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
DMSO induced Friend erythroleukemia 745.6
NCBI Gene ID #:
22042
NCBI Official Name:
transferrin receptor
NCBI Official Symbol:
Tfrc
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
Q62351
Research Area:
Cancer,Immunology,Obesity,Signal Transduction
SPECIFICITY:
CD71
Swissprot #:
Q62351
User NOte:
Optimal dilutions for each application to be determined by the researcher.