Ancell

anti-TIGIT (human) mAb (ANCTG6/10A6) (preservative free)

Product Code:
 
ANC-340-820
Product Group:
 
Primary Antibodies
Supplier:
 
Ancell
Antibody Isotype:
 
Mouse IgG1kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
ANCTG6/10A6
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Fluorescence-activated cell sorting (FACS)
Shipping:
 
BI
Storage:
 
+4°C
 

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ANC-340-820-100ug100 ug£243.00
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This product comes from: Switzerland.
Typical lead time: 10-14 working days.
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Further Information

Alternate Names/Synonyms:
T Cell Immunoreceptor with Ig and ITIM Domains; V-set and Immunoglobulin Domain-containing Protein 9; V-set and Transmembrane Domain-containing Protein 3; Vstm3; VSIG9; WUCAM
Concentration:
1mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl.
Handling Advice:
Avoid freeze/thaw cycles.Keep sterile.
Immunogen:
Recombinant human TIGIT.
Labels - Conjugates:
Preservative Free
Long Description:
Monoclonal Antibody. Binds to receptors on a subset of human peripheral blood lymphoid cells, as well as to recombinant TIGIT in EIA. Applications: ELISA, FACS. Isotype: Mouse IgG1kappa. Clone: ANCTG6/10A6. Liquid. 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl. TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a novel member of the immunoglobulin super family (IgSF). TIGIT and CD226 bind the same ligands, the two nectin-family members poliovirus receptor (PVR) and poliovirus receptor-related 2 (CD112) and compete for each other. TIGIT inhibits while CD226 activates the signaling through PVR and CD112. TIGIT and CD226 directly interact at the cell surface and this interaction impairs CD226 homodimerization and function. TIGIT is absent on naive T cells, but is expressed on activated Tregs and memory T cells, and on NK cells and NKT cells. TIGIT negatively regulates T cell activation and blockade of TIGIT exacerbates several immune diseases. TIGIT also activates the PVR receptor on dendritic cells (DCs). Addition of TIGIT (human):Fc (human) to DCs triggers phosphorylation of PVR and elicits downstream signaling, which then inhibits T cell responses by producing IL-10. TIGIT also negatively regulates NK cell cytotoxicity and cytokine production. TIGIT is directly regulated by FoxP3 and promotes inducible Treg differentiation.
NCBI, Uniprot Number:
Q495A1
Package Type:
Plastic Vial
Product Description:
TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a novel member of the immunoglobulin super family (IgSF). TIGIT and CD226 bind the same ligands, the two nectin-family members poliovirus receptor (PVR) and poliovirus receptor-related 2 (CD112) and compete for each other. TIGIT inhibits while CD226 activates the signaling through PVR and CD112. TIGIT and CD226 directly interact at the cell surface and this interaction impairs CD226 homodimerization and function. TIGIT is absent on naive T cells, but is expressed on activated Tregs and memory T cells, and on NK cells and NKT cells. TIGIT negatively regulates T cell activation and blockade of TIGIT exacerbates several immune diseases. TIGIT also activates the PVR receptor on dendritic cells (DCs). Addition of TIGIT (human):Fc (human) to DCs triggers phosphorylation of PVR and elicits downstream signaling, which then inhibits T cell responses by producing IL-10. TIGIT also negatively regulates NK cell cytotoxicity and cytokine production. TIGIT is directly regulated by FoxP3 and promotes inducible Treg differentiation.
Purity:
>95% (SDS-PAGE)
Source / Host:
Purified from concentrated hybridoma tissue culture supernatant.
Specificity:
Binds to receptors on a subset of human peripheral blood lymphoid cells, as well as to recombinant TIGIT in EIA.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at +4°C.