Nordic MuBio

Sheep anti Rat ADAR1 (Adenosine Deaminase Acting on RNA 1)

Product Code:
 
EXA-U110P
Product Group:
 
Primary Antibodies
Supplier:
 
Nordic MuBio
Host Type:
 
Sheep
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Rat
Shipping:
 
Room Temperature
Storage:
 
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
 

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EXA-U110P50 ug£316.00
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  • Further Information
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Further Information

Applications Description:
Applications: Immunoblotting - recommended dilution of 1:1000.
Background:
Double stranded RNA specific adenosine deaminase 1 (ADAR1 or DRADA) is an enzyme involved in the editing of mammalian messenger RNAs by the site specific conversion of adenosine to inosine. ADAR 1 is thought to play a role in the editing of transcripts encoding non-NMDA glutamate receptor subunits, the 2C subtype of serotonin receptor, as well as hepatitis delta virus antigen.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Signal Transduction
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
GST fusion protein containing amino acid 1116-1176 of the rat DRADA coding sequence. The fusion protein was constructed in the pGEX-KG vector by inserting a fragment corresponding to nucleotides +3346 through +3525 of DRADA at the XbaI and XhoI sites in the vector.
Product:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Product Form:
Affinity Purified
Product Stability:
Antibodies are stable for one year from purchase if stored frozen
Purification Method:
Antigen Immunoaffiinity Purification
Source:
Sheep were immunized with a GST fusion protein containing amino acid 1116-1176 of the rat DRADA coding sequence. The fusion protein was constructed in the pGEX-KG vector by inserting a fragment corresponding to nucleotides +3346 through +3525 of DRADA at the XbaI and XhoI sites in the vector.
Synonyms:
DRADA; double strandard RNA specific adenosine deaminase 1, ADAR1
UniProt:
P55266 (Rat)

References

1. Yang, J. -H., et al. 'Intracellular localization of differentially regulated RNA-specific adenosine deaminase isoforms in inflammation.' J. Biol. Chem. 2003, 278, 45833-45842

2. Wang, Q., et al. 'Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene.' J. Biol. Chem. 2004, 279, 4952-4961

3. Yang, W., et al. 'ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells.' J. Biol. Chem. 2005, 280, 3946-3953