ProSci

HEXA Antibody

Product Code:
 
PSI-14-425
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Shipping:
 
Blue Ice or RT
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded rat testis using HEXA antibody (14-425) at dilution of 1:100 (40x lens).
2 / 5
Immunohistochemistry of paraffin-embedded rat brain using HEXA antibody (14-425) at dilution of 1:100 (40x lens).
3 / 5
Immunohistochemistry of paraffin-embedded mouse testis using HEXA antibody (14-425) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse spinal cord using HEXA antibody (14-425) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse kidney using HEXA antibody (14-425) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded rat testis using HEXA antibody (14-425) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat brain using HEXA antibody (14-425) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse testis using HEXA antibody (14-425) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse spinal cord using HEXA antibody (14-425) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse kidney using HEXA antibody (14-425) at dilution of 1:100 (40x lens).

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PSI-14-425-50uL50uL£433.00
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Further Information

Additional Names:
Beta-hexosaminidase subunit alpha, Beta-N-acetylhexosaminidase subunit alpha, Hexosaminidase subunit A, N-acetyl-beta-glucosaminidase subunit alpha, HEXA
Application Note:
WB: 1:500 - 1:2000

IHC: 1:50 - 1:200
Background:
This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 270-529 of human HEXA (NP_000511.2).
NCBI Gene ID #:
3073
NCBI Official Name:
Beta-hexosaminidase subunit alpha
NCBI Official Symbol:
HEXA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Affinity purification
Research Area:
Neuroscience
Swissprot #:
P06865
User NOte:
Optimal dilutions for each application to be determined by the researcher.