South Bay Bio

20S Immunoproteasome (rat) (untagged)

Product Code:
 
SBB-PP0046
Product Group:
 
Recombinant Proteins
Supplier:
 
South Bay Bio
Regulatory Status:
 
RUO
Target Species:
 
Rat
Shipping:
 
Dry Ice
Storage:
 
-80°C
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SBB-PP0046-C05050 ug£349.00
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This product comes from: Switzerland.
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Further Information

Concentration:
Lot dependent.
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 1mM TCEP.
Handling Advice:
Aliquot to avoid freeze/thaw cycles.
Long Description:
Protein. Rat 20S Immunoproteasome. Source: Rat Spleen. Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 1mM TCEP. Purity: >95% (SDS-PAGE). The 20S immunoproteasome is structurally similar to constitutive 26S proteasome. The 20S core of immunoproteasome contains two outer rings composed of alpha-subunits, and two internal 7-subunit containing rings each possessing 3 specific subunits responsible for proteasome catalytic activity. In immunoproteasomes these subunits (beta1, beta2, beta5) are replaced by three inducible subunits: PSMB9, PSMB10 and PSMB8, (beta1i, beta2i, beta5i). These stress-induced subunits allow for the production of MHC-1 associating peptides, which are displayed as antigens on the cell surface. These displayed peptides can then be recognized by immune surveillance CD8 T cells. 20S immunoproteasome is recognized as a strong drug target for autoimmune disease and cancer.
Molecular Weight:
~700kDa
Package Type:
Plastic Vial
Product Description:
The 20S immunoproteasome is structurally similar to constitutive 26S proteasome. The 20S core of immunoproteasome contains two outer rings composed of alpha-subunits, and two internal 7-subunit containing rings each possessing 3 specific subunits responsible for proteasome catalytic activity. In immunoproteasomes these subunits (?1, ?2, ?5) are replaced by three inducible subunits: PSMB9, PSMB10 and PSMB8, (?1i, ?2i, ?5i). These stress-induced subunits allow for the production of MHC-1 associating peptides, which are displayed as antigens on the cell surface. These displayed peptides can then be recognized by immune surveillance CD8 T cells. 20S immunoproteasome is recognized as a strong drug target for autoimmune disease and cancer.
Purity:
>95% (SDS-PAGE)
Sequence:
Rat 20S Immunoproteasome.
Source / Host:
Rat Spleen
TAGs:
no TAG
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 1 year after receipt when stored at -80°C.