Further Information
Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1/SEC,MUC-1/X,MUC1/ZD,PEM,PEMT,PUM,CA 15-3,Episialin
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.8 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Mucin-1 (MUC1) is also known as Tumor-associated epithelial membrane antigen (EMA), Polymorphic epithelial mucin (PEM), Peanut-reactive urinary mucin (PUM), PEMT, Krebs von den Lungen-6 (KL-6), CD antigen CD227, Episialin, H23AG. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Except protective function by binding to pathogens, MUC1 also functions in a cell signaling capacity. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers.
- Gendler SJ., et al., 1990, J. Biol. Chem. 265 (25): 15286-93.
- Hollingsworth MA., et al., 2004, Nat. Rev. Cancer 4 (1): 45-60.
- Moncada DM., et al., 2003, Trends Parasitol 19 (7): 305-311.
- Singh PK., et al., 2006, Trends Cell Biol 16 (9): 467-476.
50 mM Tris, 100 mM Glycine, pH7.5
Fc Tag
4582
mucin 1, cell surface associated
MUC1
Homo sapiens
Lyophilized
Predicted Molecular Weight:
40.8 kDa
AAI20976
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
HEK293 cells
P15941
