ProSci

PDGF R alpha / PDGFRA Recombinant Protein

Product Code:
 
PSI-11-344
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-344-0.1mg0.1mg£657.00
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Further Information

Additional Names:
PDGFRA,CD140A,PDGFR2,RHEPDGFRA,MGC74795
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 58.4 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
PDGFRA(platelet-derived growth factor receptor A), also termed PDGFRα(platelet-derived growth factor receptor α), is a receptor located on the surface of a wide range of cell types. This receptor binds to certain isoforms of platelet-derived growth factors (PDGFs) and thereby becomes active in stimulating cell signaling pathways that elicit responses such as cellular growth and differentiation. The receptor is critical for the development of certain tissues and organs during embryogenesis and for the maintenance of these tissues and organs, particularly hematologic tissues, throughout life. Mutations in the gene which codes for PDGFRA, are associated with an array of clinically significant neoplasms.
Background References:
  • Matsui T, et al. 1989. Proc Natl Acad Sci U S A. 86(21):8314-8.
  • Kelly JD, et al. 1991. J Biol Chem. 266(14):8987-92.
  • Koschmann C, et al. 2016. Oncotarget. 7(40):65696-65706.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
5156
NCBI Official Name:
platelet derived growth factor receptor alpha
NCBI Official Symbol:
PDGFRA
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
58.4 kDa
Protein Accession #:
NP_006197.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P16234

Documents