ProSci

PSCA Recombinant Protein

Product Code:
 
PSI-11-372
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-372-0.1mg0.1mg£729.00
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Further Information

Additional Names:
PSCA,UNQ206,PRO232
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 10.4 kDa. The protein migrates as 18-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
The Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored protein, plays an important role in tumorigenesis. The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. PSCA may be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.
Background References:
  • Sakamoto H, et al. 2008. Nat Genet. 40(6):730-40.
  • Jensen MM, et al. 2015. Neurobiol Aging. 36(4):1629-1638.
  • Li E, et al. 2017. Prostate. 77(16):1563-1572.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
8000
NCBI Official Name:
prostate stem cell antigen
NCBI Official Symbol:
PSCA
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
10.4 kDa
Protein Accession #:
NP_005663.2
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
O43653

Documents