ProSci

R-Spondin 3 / RSPO3 (22-146) Recombinant Protein

Product Code:
 
PSI-11-542
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-542-0.05mg0.05mg£626.00
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Further Information

Additional Names:
RSPO3,CRISTIN1,PWTSR,THSD2
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.9 kDa. The protein migrates as 16 kDa and 19-21 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
R-Spondin 3 (RSPO3) is also called cysteine-rich and single thrombospondin domain containing-1 (CRISTIN1), Protein with TSP type-1 repeat (PWTSR), is a member of the R-spondin protein family. R-spondins (RSPO) are a recently discovered secretory protein family with four members in human and mouse. Although all four RSPO proteins activate the canonical Wnt pathway, RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. RSPO-3 is expressed ubiquitously and expressed at higher level in placenta, small intestine, fetal thymus and lymph node. RSPO3 is the activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO3 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. RSPO3 also acts as a ligand for frizzled FZD8 and LRP6 and may negatively regulate the TGF-beta pathway.
Background References:
  • Chen J.-Z., et al., 2002, Mol. Biol. Rep. 29:287-292.
  • Kim KA,, et al., 2006, Cell Cycle 5 (1): 23?6.
  • Kazanskaya O., 2004, Dev Cell 7 (4): 525?34.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
84870
NCBI Official Name:
R-spondin 3
NCBI Official Symbol:
RSPO3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
15.9 kDa
Protein Accession #:
AAH22367.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q9BXY4

Documents