ProSci

GDF-2 Recombinant Protein

Product Code:
 
PSI-11-145
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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CodeSizePrice
PSI-11-145-0.05mg0.05mg£1,042.00
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This product comes from: United States.
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Further Information

Additional Names:
GDF-2,GDF2,BMP-9,BMP9
Application Note:
This protein carries no "tag". The protein has a calculated MW of 12.1 kDa. The protein migrates as 14 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Human Growth and differentiation factor 2 (GDF-2), also known as Bone morphogenetic protein 9 (BMP-9), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors. GDF-2 Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells. Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed.
Background References:
  • Majumdar M K , Wang E , Morris E A . 2001, 189(3):275-84.
  • Scharpfenecker M , Van Dinther M , Liu Z , et al. 2007, 120(6):964.
  • Brown, M. A . Journal of Biological Chemistry, 2005, 280(26):25111-8.
Buffer:
ACN, TFA in Water
Fusion Tag:
Tag Free
Physical State:
Lyophilized
Predicted Molecular Weight:
12.1 kDa
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells

Documents