c-Myb Antibody / MYB

ELISA: 2-4ug/ml (order BSA/azide-free format)

The optimal dilution of the c-Myb antibody for each application should be determined by the researcher.

The highly leukemogenic avian retrovirus E26 contains two oncogenes, v-Myb and v-Ets, which are expressed together as a fusion protein. The cellular homolog of v-Myb, designated c-Myb, encodes a transcription factor. Deletion or disruption of a negative regulatory domain mapping within the carboxy-terminal domain of c-Myb results in enhanced transactivating capacity and in parallel, leads to activation of its ability to transform hemopoietic cells. c-Myb is expressed preferentially, but not exclusively, in immature hemopoietic cells and its expression decreases as cells differentiate.

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Amino acids 119-135 (RRKVEQEGYPQESSKAG) from the human protein were used as the immunogen for this c-Myb antibody.

This c-Myb antibody is available for research use only.

Nuclear

Protein G affinity chromatography

Human

P01104