NSJ Bioreagents

STUB1 Antibody

Product Code:
 
NSJ-F40135
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Aliquot the STUB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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CHIP / STUB1 antibody western blot analysis in MCF7 lysate. Predicted molecular weight ~35 kDa.
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STUB1 antibody western blot analysis in 1) 293 cell line and 2) human placenta lysate. Predicted molecular weight ~35 kDa.
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IHC analysis of FFPE human hepatocarcinoma tissue stained with STUB1 antibody
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IHC analysis of FFPE human hepatocarcinoma stained with the STUB1 antibody
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CHIP / STUB1 antibody western blot analysis in MCF7 lysate. Predicted molecular weight ~35 kDa.
STUB1 antibody western blot analysis in 1) 293 cell line and 2) human placenta lysate. Predicted molecular weight ~35 kDa.
IHC analysis of FFPE human hepatocarcinoma tissue stained with STUB1 antibody
IHC analysis of FFPE human hepatocarcinoma stained with the STUB1 antibody

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CodeSizePrice
NSJ-F40135-0.08ML0.08 ml£260.00
Quantity:
NSJ-F40135-0.4ML0.4 ml£502.00
Quantity:
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Further Information

Application Details :
Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
Application Note:
Titration of the STUB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
CHIP is an E3 ligase for nNOS whose action is facilitated by (and possibly requires) its interaction with nNOS-bound hsp70. Co-chaperone CHIP, possibly with another E3 ligase(s), modulates the ubiquitylation of mutant Cu/Zn-superoxide dismutase and renders them more susceptible for proteasomal degradation. CHIP functions as a negative regulator of AR transcriptional activity by promoting AR degradation. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP is associated with Parkin and enhances its ubiquitin ligase activity related to Parkinson's disease.
Format :
Antigen affinity purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 203-231 from the human protein was used as the immunogen for this STUB1 antibody.
Limitation:
This STUB1 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human
Species Reactivity (Predicted):
Mouse, Chicken
Uniprot #:
Q9UNE7