NSJ Bioreagents

L1CAM Antibody

Product Code:
 
NSJ-F44598
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Aliquot the L1CAM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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L1CAM antibody western blot analysis in mouse cerebellum tissue lysate. Expected molecular weight of glycosylated protein is 200-220 kDa.~
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L1CAM antibody western blot analysis in Jurkat lysate. Expected molecular weight of unglycosylat
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L1CAM antibody western blot analysis in mouse cerebellum tissue lysate. Expected molecular weight of glycosylated protein is 200-220 kDa.~
L1CAM antibody western blot analysis in Jurkat lysate. Expected molecular weight of unglycosylat

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CodeSizePrice
NSJ-F44598-0.08ML0.08 ml£260.00
Quantity:
NSJ-F44598-0.4ML0.4 ml£502.00
Quantity:
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Further Information

Application Details :
Western blot: 1:1000 (1)
Application Note:
Titration of the L1CAM antibody may be required due to differences in protocols and secondary/substrate sensitivity.

1. Cleavage by ADAM10 results in 180 and 40 kDa bands while cleavage by Plasmin results in 140 and 80 kDa bands.

Description:
L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
Format :
Antigen affinity purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 1154-1182 from the human protein was used as the immunogen for this L1CAM antibody.
Limitation:
This L1CAM antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse
Species Reactivity (Predicted):
Rat
Uniprot #:
P32004