Leinco Technologies

Recombinant Human IL-13 Rα1

Product Code:
 
LEI-I-544
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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LEI-I-544-100ug100 ug£614.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Interleukin 13 receptor alpha 1 (IL13Rα1), also known as CD213A1, is a subunit of the IL-13 receptor, and binds IL-13 with a low affinity by itself. IL-13 is capable of binding two types of receptor (1). One is the heterodimer composed of the IL13Rα1 and the IL4Rα , which transduces the IL-13 signals. The other is IL13Rα2 which acts as a non-signaling "decoy" receptor (2). IL13Rα1 forms a functional receptor complex for IL-13 with IL4Rα, a subunit shared by IL-13 and IL-4 receptors, transducing an IL13-dependent proliferative signal (3). IL13Rα1 also has also been shown to serve as an alternate accessory protein to the common cytokine receptor gamma chain for IL-4 signaling, but cannot replace the function of gamma C in allowing enhanced IL-2 binding activity (4). IL13Rα1 can bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL-13 and IL-4 (5). Overexpression of IL13Rα1 may play some roles in the pathogenesis of chronic stage of psoriasis.
NCBI Gene:
3596
Purity:
>90% by SDS-PAGE and analyzed by silver stain.
Target:
IL-13 R alpha 1

References

1. Caput, D. et al. (1996) J. Biol. Chem. 271:169212. Donaldson, DD. et al. (1998) J. Immunol. 161:23173. Hilton, DJ. et al. (1996) Proc. Natl. Acad. Sci. (USA) 93:4974. Zhang, JG. et al. (1997) J. Biol. Chem. 272:94745. Orchansky, PL. et al. (1999) J. Biol. Chem. 274:0818